In 2022 a global mpox outbreak, caused by clade IIb of the virus formerly called monkeypox, spread in a pattern not seen before. Transmission occurred largely through close and sexual contact, disproportionately affecting gay and bisexual men.
The response leaned on tools that already existed. The JYNNEOS vaccine, targeted testing, and clear communication with affected communities helped bring cases down. Metro Atlanta was among the areas that saw significant activity.
More recent concern about clade I disease in parts of Africa is a reminder that mpox has not gone away.
The lessons endure: reach communities without stigma, make vaccine and testing accessible, and keep clinical suspicion high for a rash illness that can be mistaken for more common conditions.